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Santhi Gorantla


Santhi Gorantla

University of Nebraska Medical Center (UNMC),Nebraska.

Biography

Dr. Santhi Gorantla is an Associate Professor at University of Nebraska Medical Center (UNMC) in Omaha. Her research career in HIV started with her first postdoctoral fellowship on “Gene therapy strategies for HIV-1 in SCID-hu mouse model” in 1997. She developed a novel “Humanized mouse model for NeuroAIDS” with established human immune system, where chronic progressive HIV infection results in immune- and central nervous system pathologies.  She recently procured a NIH R24 Resource-Related Grant to establish a Center for Humanized Mice and support researchers across US with their research using humanized mouse models. She has established several collaborative projects with investigators at UNMC and also from other institutes in US. Using humanized mouse model we are currently working on understanding CNS viral reservoirs and their behavior with drugs of abuse. We are also developing new therapeutic strategies for effective delivery of anti-retroviral drugs to target the viral reservoirs.

Abstract

Abstract : Autophagy facilitates long acting antiretroviral drug depots and controlled drug delivery