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Harold C. Smith

Harold C. Smith

Founder and CEO
University of Rochester School of Medicine


Harold C. Smith is a tenured full professor of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry and Founder and CEO of OyaGen, Inc.  His expertise is as a cell and molecular biologist with a focus in his research on the structure, function and regulation of nucleic acid protein interactions.  He is an opinion leader on the viral restriction factors known as APOBEC.  OyaGen is a drug discovery and drug development company focused on eradication of HIV/AIDS and other viral diseases through the identification of novel drug targets and small molecules that interact with these targets.


Abstract : Chemically Modified Camptothecin with Low Cytotoxicity is Broadly Neutralizing of HIV-1 as an Inhibitor of Vif-Dependent, APOBEC3G Degradation