Donatien Mavoungou
University of Health Science, Gabon
Title: Immunorex TM as vaccine approach by its ability to inhibit HIV-1 and co-infecting pathogens: The role of its Lipid fraction carrier
Biography
Biography: Donatien Mavoungou
Abstract
LCF microbicidal activity was assessed by the sensitivity using the methods of Chapman and Sabourreau. Escherichia coli (E.coli), Staphylococcus aureus, Pseudomonas and Klebsiella were isolated from the urine of HIV-1-infected patients diagnosed by western Blot technique. Various antibiotic disc (ABD) have been impregnated at 25°C with the LCF (Group 1), then dried and incubated with various germs isolated in parallel with native counter parts in Group 2. The diameters were measured (cm) to compare sensitivity between groups. LCF showed significant increase of respective antibiotics via diameter (cm): 16→28; 10→18 + Ac Claulamique for Staphylococcus aureus, LCF increased sensitivities of Amoxicilline, Cefotaxime (0→32), Netelmicine ( 20→34); Rifampicine (13→22).Cefotaxime (21→24); Aztreonam (41→48) and Amoxicilline Ac clavulamique ( 0→18) for E. coli while for Klebsiella, sensitivities to ABD was: Amoxiciline + Ac. clavulamique (20→28;24→30); Neteilmicine (20→24; 20→28); LCF showed while for Pseudomonas, negligible sensitivities to ABD. ImmunorexTM revealed potential microbicide activity that may contribute to block HIV-1 infection and the cooperation with co-infecting pathogens, protecting the unavoidable TH1 and TH2 balance in a drug and vaccine approach against HIV-1, including Tat Oyi vaccine as suggested by Biosantech, France.
