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Luise Mansky

Departments of Microbiology and Diagnostic and Biological Sciences Iowa State University, USA

Title: Attacking HIV-1 reservoirs with viral mutagens

Biography

Biography: Luise Mansky

Abstract

Multiple therapeutic approaches are being investigated towards eradicating viral reservoirs towards a cure to HIV-1 infection. Our current studies have been directed towards the discovery of viral mutagens that can eliminate the infectivity of reactivated virus through elevation of mutational load. We have found that 5-azacytidine and the combination of decitabine and gemcitabine work as potent viral mutagens and progressed in the preclinical evaluation of these antiretroviral strategies. We have discovered new antiretrovirals that also have potential for such therapeutic applications, which will be discussed